Cardiovascular responses to microinjections of urocortins into the NTS: role of inotropic glutamate receptors.

@article{Nakamura2009CardiovascularRT,
  title={Cardiovascular responses to microinjections of urocortins into the NTS: role of inotropic glutamate receptors.},
  author={Takeshi Nakamura and Hreday N. Sapru},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2009},
  volume={296 6},
  pages={
          H2022-9
        }
}
Urocortin 1 (Ucn1) and urocortin 3 (Ucn3) are new members of the corticotrophin-releasing factor (CRF) peptide family. Ucn1 is a ligand for both the CRF type 1 receptors (CRF(1)Rs) and the CRF type 2 receptors (CRF(2)Rs), whereas Ucn3 is a high-affinity ligand for the CRF(2)Rs. Recently, we reported that Ucn3 microinjections into the medial nucleus tractus solitarius (mNTS) elicit decreases in mean arterial pressure (MAP) and heart rate (HR) (Nakamura T, Kawabe K, Sapru HN. Am J Physiol Heart… CONTINUE READING

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