Cardiovascular responses to medullary microinjections of opiate agonists in urethane-anesthetized rats.

@article{Punnen1986CardiovascularRT,
  title={Cardiovascular responses to medullary microinjections of opiate agonists in urethane-anesthetized rats.},
  author={S Punnen and Hreday N. Sapru},
  journal={Journal of cardiovascular pharmacology},
  year={1986},
  volume={8 5},
  pages={950-6}
}
Pressor (VLPA) and depressor (VLDA) areas of the ventrolateral medulla were identified by microinjections of L-glutamate in urethane-anesthetized rats. Cardiovascular effects of opiate agonists microinjected into the same sites were then studied. Agents used to stimulate mu, delta, sigma, kappa, and beta-endorphin (epsilon) receptors were morphiceptin, D-Ala2-D-Leu5-enkephalin, N-allyl-normetazocine, dynorphin, and beta-endorphin, respectively. Opiate receptor stimulation in VLPA decreased… CONTINUE READING

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