• Corpus ID: 26437705

Cardiovascular responses to intracerebroventricular injection of GABA in renovascular hypertensive rats.

  title={Cardiovascular responses to intracerebroventricular injection of GABA in renovascular hypertensive rats.},
  author={A Y Sun and D X Li},
  journal={Zhongguo yao li xue bao = Acta pharmacologica Sinica},
  volume={15 2},
  • A. Y. SunD. X. Li
  • Published 1 March 1994
  • Medicine, Biology
  • Zhongguo yao li xue bao = Acta pharmacologica Sinica
Effects of central GABAergic stimulation on cardiovascular function were evaluated in 2-kidney, 1-clip (2K1C) renovascular hypertensive rats (RVHR). Intracerebroventricular injection (icv) of GABA (100 and 200 micrograms) reduced blood pressure (BP) to a greater degree in RVHR as compared with sham-operated controls, and the greatest response was seen in RVHR 4 wk after operation (4 wk-RVHR). In addition, a decreased sensitivity of baroreflex was observed in 4 wk-RVHR, and was improved by icv… 

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