Cardiovascular responses evoked by mild cool stimuli in primary Raynaud's disease: the role of endothelin.

@article{Edwards1999CardiovascularRE,
  title={Cardiovascular responses evoked by mild cool stimuli in primary Raynaud's disease: the role of endothelin.},
  author={Clare M. Edwards and Janice M. Marshall and Mari Pugh},
  journal={Clinical science},
  year={1999},
  volume={96 6},
  pages={577-88}
}
In control subjects and in subjects with primary Raynaud's disease, sudden sound evokes the pattern of the alerting response, which includes cutaneous vasoconstriction and vasodilatation in forearm muscle. However, whereas this pattern of response habituates on repetition of the sound stimulus in control subjects, both cutaneous vasoconstriction and muscle dilatation persist in subjects with primary Raynaud's disease. The aim of the present study was to test whether a similar disparity exists… CONTINUE READING

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