Corpus ID: 6311484

Cardiovascular pharmacology of the A2A adenosine receptor antagonist, SCH 58261, in the rat.

  title={Cardiovascular pharmacology of the A2A adenosine receptor antagonist, SCH 58261, in the rat.},
  author={A. Monopoli and C. Casati and G. Lozza and A. Forlani and E. Ongini},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={285 1},
  • A. Monopoli, C. Casati, +2 authors E. Ongini
  • Published 1998
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • We characterized the in vivo cardiovascular profile of SCH 58261, 7-(2-phenylethyl)-5-amino-2-(2-furyl)-pyrazolo-[4,3-e]-1,2, 4-triazolo[1,5-c] pyrimidine, a selective A2A adenosine receptor antagonist, in conscious, freely moving rats by use of the telemetry system. In normotensive rats, SCH 58261, at 10 mg/kg i.p., significantly (P < .05) inhibited hypotension and tachycardia induced by the A2A receptor agonist 2-hexynyl-5'-N-ethylcarboxamidoadenosine (0.01 mg/kg i.p.), but not the… CONTINUE READING
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    • 63
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    • 852
    Pharmacology of the highly selective A1 adenosine receptor agonist 2-chloro-N6-cyclopentyladenosine.
    • 32
    Pharmacology of adenosine A2A receptors.
    • 325
    Biochemical characterization of the triazoloquinazoline, CGS 15943, a novel, non-xanthine adenosine antagonist.
    • 108
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    • 48
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