Cardiovascular pathology in Hutchinson-Gilford progeria: correlation with the vascular pathology of aging.

@article{Olive2010CardiovascularPI,
  title={Cardiovascular pathology in Hutchinson-Gilford progeria: correlation with the vascular pathology of aging.},
  author={Michelle Olive and Ingrid A. Harten and Richard Mitchell and Jeanette K Beers and Karima Djabali and Kan Cao and Michael R Erdos and Cecilia D Blair and Birgit H Funke and Leslie B. Smoot and Marie D. Gerhard-Herman and Jason Timothy Machan and Robert Kutys and Renu Virmani and Francis S. Collins and Thomas N Wight and Elizabeth G. Nabel and Leslie B Gordon},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2010},
  volume={30 11},
  pages={2301-9}
}
OBJECTIVE Children with Hutchinson-Gilford progeria syndrome (HGPS) exhibit dramatically accelerated cardiovascular disease (CVD), causing death from myocardial infarction or stroke between the ages of 7 and 20 years. We undertook the first histological comparative evaluation between genetically confirmed HGPS and the CVD of aging. METHODS AND RESULTS We present structural and immunohistological analysis of cardiovascular tissues from 2 children with HGPS who died of myocardial infarction… CONTINUE READING
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