Cardiovascular mechanisms activated by microinjection of baclofen into NTS of conscious rats.

@article{Landulpho2003CardiovascularMA,
  title={Cardiovascular mechanisms activated by microinjection of baclofen into NTS of conscious rats.},
  author={Carlos Daniel Almeida Pitanga Landulpho and Ana Carolina Rodrigues Dias and Eduardo Colombari},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2003},
  volume={284 3},
  pages={
          H987-93
        }
}
The peripheral mechanisms responsible for pressor response produced by microinjections of baclofen (GABA(B) agonist) into the nucleus tractus solitarii (NTS) of conscious rats were studied. Bilateral microinjections of baclofen (10-1,000 pmol/100 nl) produced a dose-related increase in mean arterial pressure (MAP) and heart rate. The maximal response was observed after 15 min. Intravenous injection of prazosin decreased MAP to control levels. Subsequent treatment with Manning compound… 
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Effects of Stereotactic Introduction of Baclofen in the Medullary Cardiovascular Nuclei of Rats
TLDR
The specificities of the baclofen-induced effects are probably related to peculiarities ofThe functioning of GABAB receptors, the activation of which may mediate the effects of multiple neuronal mechanisms.
Angiotensin II enhances GABA(B) receptor-mediated responses and expression in nucleus tractus solitarii of rats.
TLDR
Results indicate that chronic ANG II infusion stimulates GABA( B) receptor expression and augments GABA(B) receptor-mediated responses in the NTS, which could contribute to the central nervous system actions of ANG II that result in dampening of baroreflexes and elevation in arterial BP.
Influence of Intraventricular Application of Baclofen on Arterial Blood Pressure and Neurotransmitter Concentrations in the Hypothalamic Paraventricular Nucleus of Rats
TLDR
It is suggested that baclofen influences the secretion of neurotransmitters and amino acids involved in autonomic activities mediated by GABAB receptors.
GABAB receptor gene transfer into the nucleus tractus solitarii induces chronic blood pressure elevation in normotensive rats.
  • B. Li, Qing Liu, +6 authors Chengwen Sun
  • Biology, Medicine
    Circulation journal : official journal of the Japanese Circulation Society
  • 2013
TLDR
Overexpression of GBR in the NTS induced a chronic elevation in blood pressure and heart rate in the normotensive WKY rats and overexposure to AAV2-GBR1 resulted in a significant increase in GBR1 expression inThe NTS neurons.
The distribution of γ-hydroxybutyrate-induced Fos expression in rat brain: Comparison with baclofen
Targeting angiotensin type 2 receptors located on pressor neurons in the nucleus of the solitary tract to relieve hypertension in mice.
TLDR
These studies unveil novel hindbrain circuits that maintain arterial blood pressure, and reveal a specific population of AT2R that can be engaged to alleviate hypertension.
Orally active vasopressin V1a receptor antagonist, SRX251, selectively blocks aggressive behavior
GABAergic contribution to the muscle mechanoreflex-mediated heart rate responses at the onset of exercise in humans.
TLDR
It is found that passive and voluntary cycling evokes similar increases in heart rate and that these responses were enhanced after diazepam administration, a benzodiazepine that enhances GABAA activity, suggesting that the GABAergic system may contribute to the muscle mechanoreflex-mediated vagal withdrawal at the onset of exercise in humans.
GabaB receptors activation in the NTS blocks the glycemic responses induced by carotid body receptor stimulation
O ÓXIDO NÍTRICO (NO) NO CONTROLE NEURAL DA PRESSÃO ARTERIAL: MODULAÇÃO DA TRANSMISSÃO GLUTAMATÉRGICA NO NTS
O efeito neuromodulatorio do oxido nitrico (NO) sobre a transmissao glutamatergica no NTS relacionado ao controle cardiovascular tem sido bastante investigado. A ativacao de receptores…
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References

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