Cardiovascular magnetic resonance risk stratification in patients with clinically suspected myocarditis

@article{Schumm2014CardiovascularMR,
  title={Cardiovascular magnetic resonance risk stratification in patients with clinically suspected myocarditis},
  author={Julia Schumm and Simon Greulich and Anja Wagner and Stefan Gr{\"u}n and Peter Ong and Kerstin Bentz and Karin Klingel and Reinhard Kandolf and Oliver Bruder and Steffen Schneider and Udo Sechtem and Heiko Mahrholdt},
  journal={Journal of Cardiovascular Magnetic Resonance},
  year={2014},
  volume={16},
  pages={14 - 14}
}
BackgroundThe diagnosis of myocarditis is challenging due to its varying clinical presentation. Since myocarditis can be associated with significant 5-year mortality, and postmortem data show myocarditis in almost 10% of all adults suffering sudden cardiac death, individual risk stratification for patients with suspected myocarditis is of great clinical interest. We sought to demonstrate that patients with clinically suspected myocarditis and a normal cardiovascular magnetic resonance (CMR… Expand
Prognostic Value of Cardiac Magnetic Resonance Tissue Characterization in Risk Stratifying Patients With Suspected Myocarditis.
TLDR
CMR tissue characterization provides effective risk stratification in patients with suspected myocarditis with regard to CMR findings, and the computed continuous net reclassification improvement by LGE markers is determined. Expand
Cardiovascular magnetic resonance predictors of clinical outcome in patients with suspected acute myocarditis
TLDR
In routine consecutive patients without severe hemodynamic compromise and a CMR-based diagnosis of AM, various CMR parameters such as the presence and extent of myocardial edema and the extent of late gadolinium-enhanced LV myocardia lesions were not predictive of outcome. Expand
Update on acute myocarditis
TLDR
A risk-based approach should be promoted in order to identify the most severe AM cases requiring appropriate bundles of care, including early recognition, transfer to tertiary centers, aggressive circulatory supports with inotropes and mechanical devices, histologic confirmation and eventual immunosuppressive therapy. Expand
Diagnostic and prognostic role of cardiac magnetic resonance in acute myocarditis
TLDR
Cardiac magnetic resonance should be routinely performed in all patients with AM suspicion since its diagnostic and prognostic role is of paramount important and could modify therapeutic strategy and subsequent clinical decisions. Expand
Cardiovascular magnetic resonance techniques and findings in children with myocarditis: a multicenter retrospective study
TLDR
Despite significant practice variation in imaging protocol among centers, CMR had a high sensitivity for the diagnosis of myocarditis in pediatric patients and should be useful in designing future prospective studies. Expand
Clinical and magnetic resonance evolution of “infarct-like” myocarditis
TLDR
Patients diagnosed with “infarct-like” myocarditis, according to both clinical and CMR examinations may look forward to a positive evolution with a good prognosis. Expand
Utility of cardiac MRI in paediatric myocarditis
TLDR
In paediatric myocarditis, cardiac MRI is not used uniformly, has a low yield, and does not predict worse outcomes, according to a new prognostic score for risk stratification. Expand
Prognosis in Myocarditis: Better Late Than (N)ever!
TLDR
Cardiovascular magnetic resonance (CMR) seems to be the method of choice for work-up and risk stratification in myocarditis, and has proven prognostic value, because LGE-positive patients are at increased risk for adverse events and L GE-negative patients have an excellent prognosis independent of their clinical symptoms. Expand
Speckle tracking imaging in inflammatory heart diseases
TLDR
Speckle tracking imaging based EF correlates with CMR calculated LVEF and with global strain, and can help in the diagnosis of acute myocarditis when CMR is not readily available. Expand
Association of ECG parameters with late gadolinium enhancement and outcome in patients with clinical suspicion of acute or subacute myocarditis referred for CMR imaging
TLDR
In patients with clinically suspected myocarditis, abnormal ECG parameters are associated with abnormal tissue characteristics detected by CMR, and ECG and CMR findings have independent prognostic implications for morbidity and mortality. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 24 REFERENCES
Cardiovascular Magnetic Resonance Assessment of Human Myocarditis: A Comparison to Histology and Molecular Pathology
TLDR
Contrast enhancement is a frequent finding in the clinical setting of suspected myocarditis and is associated with active inflammation defined by histopathology and is a valuable tool for the evaluation and monitoring of inflammatory heart disease. Expand
Long-term follow-up of biopsy-proven viral myocarditis: predictors of mortality and incomplete recovery.
TLDR
Among the authors' population with a wide range of clinical symptoms, biopsy-proven viral myocarditis is associated with a long-term mortality of up to 19.2% in 4.7 years, and the presence of LGE is the best independent predictor of all-cause mortality and of cardiac mortality. Expand
Predictors of Outcome in Patients With Suspected Myocarditis
TLDR
For patients with suspected myocarditis, advanced New York Heart Association functional class, immunohistological signs of inflammation, and lack of β-blocker therapy, but not histology (positive Dallas criteria) or viral genome detection, are related to poor outcome. Expand
CMR imaging predicts death and other adverse events in suspected cardiac sarcoidosis.
TLDR
Among the population of sarcoid patients with nonspecific symptoms, the presence of myocardial scar indicated by LGE was the best independent predictor of potentially lethal events, as well as other adverse events, yielding a Cox HR of 31.6 and of 33.9. Expand
Presentation, Patterns of Myocardial Damage, and Clinical Course of Viral Myocarditis
TLDR
The data indicate that PVB19 and HHV6 are the most important causes for viral myocarditis in Germany and that the clinical presentation is related to the type of virus. Expand
Diagnostic performance of cardiovascular magnetic resonance in patients with suspected acute myocarditis: comparison of different approaches.
TLDR
A combined CMR approach using T2-weighted imaging, early and late gadolinium enhancement, provides a high diagnostic accuracy and is a useful tool in the diagnosis and assessment of patients with suspected acute myocarditis. Expand
Delayed gadolinium-enhanced cardiac magnetic resonance in patients with chronic myocarditis presenting with heart failure or recurrent arrhythmias.
TLDR
It is suggested that CE-CMR may be a useful non-invasive diagnostic tool in patients with CM, and it may indicate and even guide the execution of left ventricular EMB with relevant prognostic and therapeutic implications. Expand
Cardiovascular magnetic resonance, fibrosis, and prognosis in dilated cardiomyopathy.
TLDR
In DCM, midwall fibrosis determined by CMR is a predictor of the combined end point of all-cause mortality and cardiovascular hospitalization, which is independent of ventricular remodeling, which suggests a potential role for CMR in the risk stratification of patients with DCM. Expand
Development of diastolic heart failure in a 6-year follow-up study in patients after acute myocarditis
TLDR
It is assumed that the evidence for AMC is associated not only with the risk of developing LV dilatation but also with an increased risk of symptomatic diastolic dysfunction after several years. Expand
Association of fibrosis with mortality and sudden cardiac death in patients with nonischemic dilated cardiomyopathy.
IMPORTANCE Risk stratification of patients with nonischemic dilated cardiomyopathy is primarily based on left ventricular ejection fraction (LVEF). Superior prognostic factors may improve patientExpand
...
1
2
3
...