Cardiovascular interactions of nonivamide, glyceryl nonivamide, capsaicin analogues, and substance P antagonist in rats.

@article{Yeh1993CardiovascularIO,
  title={Cardiovascular interactions of nonivamide, glyceryl nonivamide, capsaicin analogues, and substance P antagonist in rats.},
  author={Jwu-Lai Yeh and Y C Lo and Yang Wang and I Jen Chen},
  journal={Brain research bulletin},
  year={1993},
  volume={30 5-6},
  pages={641-8}
}
Nonanoyl vanillylamide-4-o-glycerol (glyceryl nonivamide, GLNVA) a nonpungent ether-linked derivative of nonanoyl vanillylamide (nonivamide, NVA) was compared to capsaicin (CAP) and NVA with regard to its depressor response in rats. IV injection of CAP and NVA (10(-1) to 10(-4) mg/kg) in Wistar rats elicit a triphasic blood pressure response, bradycardia, and aponea. However, IV injection of GLNVA results in a monophasic reduction in blood pressure, with little effect on heart rate and… CONTINUE READING