Cardiovascular interaction of nicotine, ergonovine, and hypercholesterolemia in the rabbit.


A HIGH incidence of myocardial necrosis and lesions of the feet and lower legs has been demonstrated in rabbits treated with nicotine and a hypercholesterolemic diet. Peripheral circulatory changes were marked in all rabbits on the hypercholesterolemic diet, but the effects were more severe and occurred earlier in the course of treatment for those animals… (More)


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