Cardiovascular influences of alpha1b-adrenergic receptor defect in mice.


BACKGROUND The alpha1-adrenergic receptors (alpha1-ARs) play a key role in cardiovascular homeostasis. However, the functional role of alpha1-AR subtypes in vivo is still unclear. The aim of this study was to evaluate the cardiovascular influences of alpha1b-AR. METHODS AND RESULTS In transgenic mice lacking alpha1-AR (KO) and their wild-type controls (WT… (More)


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@article{Vecchione2002CardiovascularIO, title={Cardiovascular influences of alpha1b-adrenergic receptor defect in mice.}, author={Carmine Vecchione and Luigi Fratta and Damiano Rizzoni and Antonella Notte and Roberta Poulet and Enzo Porteri and Giacomo Frati and Daniele Guelfi and Valentina Trimarco and Michael J. Mulvany and Enrico Agabiti-Rosei and Bruno Trimarco and Susanna Cotecchia and Giuseppe Lembo}, journal={Circulation}, year={2002}, volume={105 14}, pages={1700-7} }