Cardiovascular function in acromegaly.

  title={Cardiovascular function in acromegaly.},
  author={Richard N. Clayton},
  journal={Endocrine reviews},
  volume={24 3},
Even with modern treatment, acromegaly is associated with a 2- to 3-fold increase in mortality, mainly from vascular disease, which is probably a result of the long exposure of tissues to excess GH before diagnosis and treatment. There is accumulating evidence that effective treatment to lower serum GH levels to less than 1-2 ng/ml (glucose suppressed or random, respectively) and normalize IGF-I improves long-term outcome and survival. In addition to recognized cardiovascular risk factors of… CONTINUE READING