Cardiovascular features of homozygous familial hypercholesterolemia: analysis of 16 patients.

@article{Sprecher1984CardiovascularFO,
  title={Cardiovascular features of homozygous familial hypercholesterolemia: analysis of 16 patients.},
  author={Dennis L. Sprecher and Ernst J. Schaefer and Kenneth M. Kent and Richard E. Gregg and Loren A Zech and Jeffrey M. Hoeg and Bruce Mcmanus and William Clifford Roberts and Hollis B Brewer},
  journal={The American journal of cardiology},
  year={1984},
  volume={54 1},
  pages={20-30}
}
Familial hypercholesterolemia (FH) is characterized by an autosomal codominant inheritance, an abnormality in low-density lipoprotein (LDL) receptor function, elevated plasma cholesterol levels and premature atherosclerosis. Sixteen patients with homozygous FH were studied to correlate the extent of their atherosclerotic disease with their lipid levels and receptor function. The age range at initial presentation was 3 to 38 years (mean 12), and at the last examination, 6 to 43 years (mean 20… CONTINUE READING
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