Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial.
@article{Bresalier2005CardiovascularEA, title={Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial.}, author={Robert S. Bresalier and Robert S. Sandler and Hui Quan and James A. Bolognese and Bettina Oxenius and Kevin J. Horgan and Christopher R. Lines and Robert H Riddell and Dion G. Morton and {\'A}ngel Lanas and Marvin A. Konstam and John A. Baron}, journal={The New England journal of medicine}, year={2005}, volume={352 11}, pages={ 1092-102 } }
BACKGROUND
Selective inhibition of cyclooxygenase-2 (COX-2) may be associated with an increased risk of thrombotic events, but only limited long-term data have been available for analysis. We report on the cardiovascular outcomes associated with the use of the selective COX-2 inhibitor rofecoxib in a long-term, multicenter, randomized, placebo-controlled, double-blind trial designed to determine the effect of three years of treatment with rofecoxib on the risk of recurrent neoplastic polyps of…
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A randomized trial of rofecoxib for the chemoprevention of colorectal adenomas.
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In this randomized trial, rofecoxib significantly reduced the risk of colorectal adenomas, but also had serious toxicity.
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Celecoxib use was associated with a dose-related increase in the composite end point of death from cardiovascular causes, myocardial infarction, stroke, or heart failure, providing further evidence that the use of COX-2 inhibitors may increase the risk of serious cardiovascular events.
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Rofecoxib therapy was associated with an increased frequency of adverse cardiovascular events among patients with a median study treatment of 7.4 months' duration, and died from cardiovascular causes during the follow-up period.
Peptic ulcer and bleeding events associated with rofecoxib in a 3-year colorectal adenoma chemoprevention trial.
- MedicineGastroenterology
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Among patients with a history of colorectal adenomas, the long-term use of 25 mg/day of rofecoxib was associated with an increased risk of clinically relevant upper gastrointestinal events when compared with placebo.
COX 2 inhibitors, traditional NSAIDs, and the heart
- MedicineBMJ : British Medical Journal
- 2005
Rofecoxib had been marketed as the non-steroidal anti-inflammatory drug (NSAID) of choice because selective inhibition of the isoform 2 of the cyclooxygenase (COX 2) enzyme made it highly effective but free from gastrointestinal toxicity.
Risk of cardiovascular events in patients receiving celecoxib: a meta-analysis of randomized clinical trials.
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Cardiovascular events associated with the long-term use of NSAIDs: a review of randomized controlled trials and observational studies
- MedicineExpert opinion on drug safety
- 2014
Results are ambiguous: long-term exposure seemed associated with an increased risk of myocardial infarction or stroke with high-dose rofecoxib, and perhaps diclofenac, but less with other NSAIDs, since most NSAIDs are rarely used long term.
Relative Thromboembolic Risks Associated with COX-2 Inhibitors
- MedicineThe Annals of pharmacotherapy
- 2005
OBJECTIVE To evaluate the clinical literature on cyclooxygenase-2 (COX-2) inhibitors to determine whether a greater incidence of thromboembolic events is universal within the drug class. DATA SOURCES…
Effect of Celecoxib on Cardiovascular Events and Blood Pressure in Two Trials for the Prevention of Colorectal Adenomas
- MedicineCirculation
- 2006
Background— Cyclooxygenase-2 (COX-2) inhibitors have been shown to reduce colorectal adenomas but have been associated with increased cardiovascular risk. Methods and Results— The Adenoma Prevention…
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