• DOI:10.1056/NEJMOA050493
Corpus ID: 8161299

Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial.

@article{Bresalier2005CardiovascularEA,
  title={Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial.},
  author={R. Bresalier and R. Sandler and H. Quan and J. Bolognese and B. Oxenius and K. Horgan and C. Lines and R. Riddell and D. Morton and {\'A}. Lanas and M. Konstam and J. Baron},
  journal={The New England journal of medicine},
  year={2005},
  volume={352 11},
  pages={
          1092-102
        }
}

• R. Bresalier, R. Sandler, +9 authors J. Baron
• Published 2005
• Medicine
• The New England journal of medicine

BACKGROUND Selective inhibition of cyclooxygenase-2 (COX-2) may be associated with an increased risk of thrombotic events, but only limited long-term data have been available for analysis. We report on the cardiovascular outcomes associated with the use of the selective COX-2 inhibitor rofecoxib in a long-term, multicenter, randomized, placebo-controlled, double-blind trial designed to determine the effect of three years of treatment with rofecoxib on the risk of recurrent neoplastic polyps of… Expand

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