Cardiovascular endocrinology in 2012: PCSK9—an exciting target for reducing LDL-cholesterol levels

@article{Betteridge2013CardiovascularEI,
  title={Cardiovascular endocrinology in 2012: PCSK9—an exciting target for reducing LDL-cholesterol levels},
  author={D. John Betteridge},
  journal={Nature Reviews Endocrinology},
  year={2013},
  volume={9},
  pages={76-78}
}
  • D. J. Betteridge
  • Published 8 January 2013
  • Medicine, Biology
  • Nature Reviews Endocrinology
Systemic administration of anti-PCSK9 antibodies induces dramatic reductions in LDL-cholesterol levels, and the effect of this therapy on LDL-receptor activity seems to be additive to that of statin therapy. Inhibition of PCSK9 is potentially very important to the clinician, and should enable more patients to achieve their LDL-cholesterol-level goal. 
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TLDR
In this phase 2 study in statin-intolerant patients, subcutaneous administration of a monoclonal antibody to PCSK9 significantly reduced LDL cholesterol levels and was associated with short-term tolerability.
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It is found that REGN727/SAR236553 (REGN727), a human proprotein convertase subtilisin/kexin 9 (PCSK9) monoclonal antibody, lowers levels of low-density lipoprotein (LDL) cholesterol in patients with familial and nonfamilial hypercholesterolemia.
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