Cardiovascular effects produced by microinjection of angiotensins and angiotensin antagonists into the ventrolateral medulla of freely moving rats

@article{Fontes1997CardiovascularEP,
  title={Cardiovascular effects produced by microinjection of angiotensins and angiotensin antagonists into the ventrolateral medulla of freely moving rats},
  author={Marco Ant{\^o}nio Peliky Fontes and Marli Cardoso Martins Pinge and Veloso Naves and Maria Jose Campagnole-Santos and Robson Augusto Souza Santos},
  journal={Brain Research},
  year={1997},
  volume={750},
  pages={305-310}
}
In this study we determined the cardiovascular effects produced by microinjection of angiotensin peptides [Angiotensin-(1-7) and Angiotensin II] and angiotensin antagonists (losartan, L-158,809, CGP 42112A. Sar1-Thr8-Ang II, A-779) into the rostral ventrolateral medulla of freely moving rats. Microinjection of angiotensins (12.5-50 pmol) produced pressor responses associated to variable changes in heart rate, usually tachycardia. Unexpectedly, microinjection of both AT1 and AT2 ligands produced… CONTINUE READING

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