Cardiovascular effects of tyramine: adrenergic and cholinergic interactions.

@article{Khwanchuea2008CardiovascularEO,
  title={Cardiovascular effects of tyramine: adrenergic and cholinergic interactions.},
  author={Rapheeporn Khwanchuea and Michael J. Mulvany and Chaweewan Jansakul},
  journal={European journal of pharmacology},
  year={2008},
  volume={579 1-3},
  pages={
          308-17
        }
}
The vascular effects of trace amines and amphetamines.
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Investigation of trace amine receptors in the cardiovascular systems
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p‐Synephrine, ephedrine, p‐octopamine and m‐synephrine: Comparative mechanistic, physiological and pharmacological properties
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The effects of ephedrine and m‐synephrine cannot be directly extrapolated to p‐ synephrine and p‐octopamine which exhibit significantly different pharmacokinetic, and physiological/pharmacological properties.
High intake of dietary tyramine does not deteriorate glucose handling and does not cause adverse cardiovascular effects in mice
TLDR
The lack of serious adverse cardiovascular effects of prolonged tyramine supplementation in normoglycemic mice together with the somewhat insulin-like effects found on adipose cells should lead to reconsider favourably the risk/benefit ratio of the intake of this dietary amine.
The hemostatic effect study of Cirsium setosum on regulating α1-ARs via mediating norepinephrine synthesis by enzyme catalysis.
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References

SHOWING 1-10 OF 30 REFERENCES
Influence of adrenoceptor and muscarinic receptor blockade on the cardiovascular effects of exogenous noradrenaline and of endogenous noradrenaline released by infused tyramine
TLDR
The cardiovascular effects of exogenous noradrenaline are mainly characterized by α1-adrenoceptor-mediated vasoconstriction and the actions of endogenous norad Renaline (released by i.v. tyramine) by β1- adreno receptor-mediated positive inotropic effects.
Influence of atropine on the cardiovascular effects of noradrenaline and tyramine in elder volunteers
TLDR
The results indicate that ageing is accompanied by a blunted baroreflex-mediated parasympathetic activation resulting in reduced cholinergic vasodilation and decreases in heart rate, and that aging is associated with a decreased responsiveness of (cardiac) β-adrenoceptors and (vascular) α1-ad Renalceptors which is only unmasked when the counterregulatory action of parasyMPathetic activation is removed.
Oral tyramine pressor test and the safety of monoamine oxidase inhibitor drugs: comparison of brofaromine and tranylcypromine in healthy subjects.
TLDR
The probability of "cheese reactions" during treatment with this reversible MAOI seems to be small, and delays of 8 and 30 days after the last doses of BROF and TCP, respectively, are needed for complete normalization of oral pressor responsiveness.
Acetylcholine release from rat atria can be regulated through an alpha 1-adrenergic receptor.
TLDR
It is suggested that the release of acetylcholine from cardiac parasympathetic neurons can be regulated through an alpha 1-adrenergic receptor, and that this mechanism may underly, at least in part, the relative lack of effects of prazosin on heart rate.
Antagonism by propranolol of the cardiac chronotropic response to norepinephrine or to transmural electrical stimulation.
  • E. Thompson, T. West
  • Biology, Medicine
    The Journal of pharmacology and experimental therapeutics
  • 1968
TLDR
Although the displacement of the concentration- response curves and the frequency-response curves suggests a difference in the mechanism of blockade by propranolol in the two cases, it is postulated that in both cases the blockade is the result of surmountable inhibition.
The release of3H-noradrenaline by p- and m-tyramines and -octopamines, and the effect of deuterium substitution in α-position
TLDR
Analysis of the efflux of3H-DOPEG confirmed that this gain in the relative potencies of octopamines is due to their increased ability to mobilize vesicular 3H-noradrenaline; moreover, deuterated amines as well were then better mobilizers than were their parent amines.
Pressor Response to Intravenous Tyramine Is a Marker of Cardiac, but Not Vascular, Adrenergic Function
TLDR
The results suggest that pressor responses during tyramine injections are primarily due to an inotropic response that increases cardiac output and pressure and causes a reflex decrease in vascular resistance.
INHIBITION OF SYMPATHOMIMETIC EFFECTS ON THE HEART.
The adrenaline beta-receptor blocking drug, pronethalol, and the sympathomimetic amines, (-)-ephedrine, (-)-amphetamine, dexamphetamine, (-)-Psi-ephedrine and tyramine, inhibited the sympathomimetic
...
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