Cardiovascular effects of tyramine: adrenergic and cholinergic interactions.

  title={Cardiovascular effects of tyramine: adrenergic and cholinergic interactions.},
  author={Rapheeporn Khwanchuea and Michael J. Mulvany and Chaweewan Jansakul},
  journal={European journal of pharmacology},
  volume={579 1-3},
The vascular effects of trace amines and amphetamines.
  • K. Broadley
  • Biology, Chemistry
    Pharmacology & therapeutics
  • 2010
Investigation of trace amine receptors in the cardiovascular systems
The molecular biological confirmation of the presence of TAAR1 and the pharmacological findings regarding the effects of TAs in rat aortic rings might explain their hypertensive effects and their role in coronary heart disease and migraine headache.
The contributions of muscarinic receptors and changes in plasma aldosterone levels to the anti-hypertensive effect of Tulbaghia violacea
It is suggested that stimulation of the muscarinic receptors and a reduction in plasma aldosterone levels contribute to the anti-hypertesive effect of T. violacea.
Development of sympathetic cardiovascular control in embryonic, hatchling, and yearling female American alligator (Alligator mississippiensis).
p‐Synephrine, ephedrine, p‐octopamine and m‐synephrine: Comparative mechanistic, physiological and pharmacological properties
The effects of ephedrine and m‐synephrine cannot be directly extrapolated to p‐ synephrine and p‐octopamine which exhibit significantly different pharmacokinetic, and physiological/pharmacological properties.
High intake of dietary tyramine does not deteriorate glucose handling and does not cause adverse cardiovascular effects in mice
The lack of serious adverse cardiovascular effects of prolonged tyramine supplementation in normoglycemic mice together with the somewhat insulin-like effects found on adipose cells should lead to reconsider favourably the risk/benefit ratio of the intake of this dietary amine.
The hemostatic effect study of Cirsium setosum on regulating α1-ARs via mediating norepinephrine synthesis by enzyme catalysis.


Influence of adrenoceptor and muscarinic receptor blockade on the cardiovascular effects of exogenous noradrenaline and of endogenous noradrenaline released by infused tyramine
The cardiovascular effects of exogenous noradrenaline are mainly characterized by α1-adrenoceptor-mediated vasoconstriction and the actions of endogenous norad Renaline (released by i.v. tyramine) by β1- adreno receptor-mediated positive inotropic effects.
Influence of atropine on the cardiovascular effects of noradrenaline and tyramine in elder volunteers
The results indicate that ageing is accompanied by a blunted baroreflex-mediated parasympathetic activation resulting in reduced cholinergic vasodilation and decreases in heart rate, and that aging is associated with a decreased responsiveness of (cardiac) β-adrenoceptors and (vascular) α1-ad Renalceptors which is only unmasked when the counterregulatory action of parasyMPathetic activation is removed.
Oral tyramine pressor test and the safety of monoamine oxidase inhibitor drugs: comparison of brofaromine and tranylcypromine in healthy subjects.
The probability of "cheese reactions" during treatment with this reversible MAOI seems to be small, and delays of 8 and 30 days after the last doses of BROF and TCP, respectively, are needed for complete normalization of oral pressor responsiveness.
Acetylcholine release from rat atria can be regulated through an alpha 1-adrenergic receptor.
It is suggested that the release of acetylcholine from cardiac parasympathetic neurons can be regulated through an alpha 1-adrenergic receptor, and that this mechanism may underly, at least in part, the relative lack of effects of prazosin on heart rate.
Antagonism by propranolol of the cardiac chronotropic response to norepinephrine or to transmural electrical stimulation.
  • E. Thompson, T. West
  • Biology, Medicine
    The Journal of pharmacology and experimental therapeutics
  • 1968
Although the displacement of the concentration- response curves and the frequency-response curves suggests a difference in the mechanism of blockade by propranolol in the two cases, it is postulated that in both cases the blockade is the result of surmountable inhibition.
The release of3H-noradrenaline by p- and m-tyramines and -octopamines, and the effect of deuterium substitution in α-position
Analysis of the efflux of3H-DOPEG confirmed that this gain in the relative potencies of octopamines is due to their increased ability to mobilize vesicular 3H-noradrenaline; moreover, deuterated amines as well were then better mobilizers than were their parent amines.
Pressor Response to Intravenous Tyramine Is a Marker of Cardiac, but Not Vascular, Adrenergic Function
The results suggest that pressor responses during tyramine injections are primarily due to an inotropic response that increases cardiac output and pressure and causes a reflex decrease in vascular resistance.
The adrenaline beta-receptor blocking drug, pronethalol, and the sympathomimetic amines, (-)-ephedrine, (-)-amphetamine, dexamphetamine, (-)-Psi-ephedrine and tyramine, inhibited the sympathomimetic