Cardiovascular effects of two xanthines and the relation to adenosine antagonism

  title={Cardiovascular effects of two xanthines and the relation to adenosine antagonism},
  author={P. Smits and J. Schouten and T. Thien},
  journal={Clinical Pharmacology & Therapeutics},
  • P. Smits, J. Schouten, T. Thien
  • Published 1989
  • Chemistry, Medicine
  • Clinical Pharmacology & Therapeutics
  • We hypothesize that the hemodynamic effects of xanthine derivatives depend on their ability to antagonize the vasodilating effects of endogenous adenosine. In a randomized, double‐blind, and placebo‐controlled study of 10 normotensive volunteers caffeine, a xanthine with in vitro adenosine antagonistic properties, increased mean arterial pressure by 5.6 ± 0.9 mm Hg and lowered heart rate by 5.3 ±1.1 beats/min. After administration of enprofylline, a xanthine without adenosine antagonism… CONTINUE READING
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