Cardiovascular effects of the thiazolidinediones.

  title={Cardiovascular effects of the thiazolidinediones.},
  author={Rehan Qayyum and Peter Schulman},
  journal={Diabetes/metabolism research and reviews},
  volume={22 2},
Thiazolidinediones, used for the treatment of diabetes mellitus type 2, modulate gene expression by binding to nuclear transcription factor, peroxisome proliferator-activated receptor-gamma. Peroxisome proliferator-activated receptor-gamma is expressed in several tissues, therefore, thiazolidinediones have biological effects on multiple organ systems. Here, we describe evidence that thiazolidinediones have beneficial effects on the cardiovascular system independent of their antidiabetic effect… CONTINUE READING


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