Cardiovascular effects of sphingosine-1-phosphate and other sphingomyelin metabolites.

  title={Cardiovascular effects of sphingosine-1-phosphate and other sphingomyelin metabolites.},
  author={Astrid E. Alewijnse and Stephan L. M. Peters and Martin C Michel},
  journal={British journal of pharmacology},
  volume={143 6},
Upon various stimuli, cells metabolize sphingomyelin from the cellular plasma membrane to form sphingosylphosphorylcholine (SPC) or ceramide. The latter can be further metabolized to sphingosine and then sphingosine-1-phosphate (S1P). Apart from local formation, S1P and SPC are major constituents of blood plasma. All four sphingomyelin metabolites (SMM) can act upon intracellular targets, and at least S1P and probably also SPC can additionally act upon G-protein-coupled receptors. While the… CONTINUE READING


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