Cardiovascular effects of single oral doses of the new beta-adrenoceptor blocking agents betaxolol (SL 75212) in healthy volunteers.

@article{Cadigan1980CardiovascularEO,
  title={Cardiovascular effects of single oral doses of the new beta-adrenoceptor blocking agents betaxolol (SL 75212) in healthy volunteers.},
  author={Penelope Cadigan and D. Jarvis London and BrianL. Pentecost and Gabrio Bianchetti and Roberto Gomeni and Judith Kilborn and Paolo Lucio Morselli},
  journal={British journal of clinical pharmacology},
  year={1980},
  volume={9 6},
  pages={
          569-75
        }
}
1 The effects of betaxolol (SL 75212), a new beta-adrenoceptor blocking agent, on the cardiovascular response to exercise have been studied in six normal subjects after placebo and single oral doses of 5, 10, 20 and 40 mg given double-blind in a randomized sequence. 2 All doses reduced exercise heart rate, with a significant reduction persisting to 23 h after doses of 20 mg and 40 mg. Systolic blood pressure on exercise was reduced after all doses, with a reduction continuing to 23 h after… CONTINUE READING
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