Cardiovascular effects of nitric oxide in the rostral ventrolateral medulla of rats.

@article{Kagiyama1997CardiovascularEO,
  title={Cardiovascular effects of nitric oxide in the rostral ventrolateral medulla of rats.},
  author={Shuntaro Kagiyama and Takuya Tsuchihashi and Isao Abe and Masatoshi Fujishima},
  journal={Brain research},
  year={1997},
  volume={757 1},
  pages={155-8}
}
To investigate the cardiovascular role of nitric oxide (NO) in the rostral ventrolateral medulla (RVLM), NOC 18, an NO donor, was microinjected into the RVLM of rats. NOC 18 significantly decreased mean arterial pressure (MAP). Pre-treatment with an NO trapper, carboxy-PTIO, abolished the NOC 18-induced decrease in MAP. Microinjection of L-NAME, an NO synthase inhibitor, increased MAP. L-Arginine reduced MAP and inhibited the pressor response induced by L-NAME. Results suggest that NO acts on… CONTINUE READING

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