Cardiovascular effects of melanocortins.

  title={Cardiovascular effects of melanocortins.},
  author={Michael H. Humphreys and X P Ni and David Pearce},
  journal={European journal of pharmacology},
  volume={660 1},
Melanocortins (MSH's) are three structurally related peptides derived from proopiomelanocortin. They regulate several physiologic functions including energy metabolism, appetite, and inflammation. Recent work in rodents has also identified important effects of MSH's, particularly γ-MSH, on sodium metabolism and blood pressure regulation. Normal rats and mice respond to a high sodium diet with an increase in the plasma concentration of γ-MSH, and remain normotensive, while those with genetic or… CONTINUE READING


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