Cardiovascular effects of leptin and orexins.

  title={Cardiovascular effects of leptin and orexins.},
  author={Tetsuro Shirasaka and Mayumi Takasaki and Hiroshi Kannan},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={284 3},
Leptin, the product of the ob gene, is a satiety factor secreted mainly in adipose tissue and is part of a signaling mechanism regulating the content of body fat. It acts on leptin receptors, most of which are located in the hypothalamus, a region of the brain known to control body homeostasis. The fastest and strongest hypothalamic response to leptin in ob/ob mice occurs in the paraventricular nucleus, which is involved in neuroendocrine and autonomic functions. On the other hand, orexins… CONTINUE READING


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