Cardiovascular effects of intravenous administered 26RFa, a novel RFamide peptide ligand for GPR103, in anaesthetised rats.

@article{Fang2009CardiovascularEO,
  title={Cardiovascular effects of intravenous administered 26RFa, a novel RFamide peptide ligand for GPR103, in anaesthetised rats.},
  author={Quan Fang and Qian Liu and Ning Li and Tian-nan Jiang and Yu-Lin Li and Xiang Yan and Rui Wang},
  journal={European journal of pharmacology},
  year={2009},
  volume={621 1-3},
  pages={
          61-6
        }
}
26RFa, a novel RFamide-related peptide, has been identified as the endogenous ligand for GPR103, and the biological functions of this neuropeptide have not been well investigated. In the present study, the cardiovascular effects of intravenous administration of rat/mouse 26RFa were tested in rats. Intravenous administered 26RFa (100-800 nmol/kg, i.v.) caused a biphasic change in blood pressure, and an increase in heart rate in urethane-anaesthetised rats. The pressor effects induced by 26RFa… CONTINUE READING
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