Cardiovascular effects of intracerebroventricular injection of vasopressin in unanaesthetized normotensive and DOCA-salt hypertensive rats.

@article{Berecek1984CardiovascularEO,
  title={Cardiovascular effects of intracerebroventricular injection of vasopressin in unanaesthetized normotensive and DOCA-salt hypertensive rats.},
  author={Kathleen H. Berecek and S C Mah and Petra Baum and Karl G. Hofbauer},
  journal={Journal of hypertension. Supplement : official journal of the International Society of Hypertension},
  year={1984},
  volume={2 3},
  pages={S29-31}
}
The mean arterial pressure (MAP) and heart rate (HR) responses to intracerebroventricular (i.c.v.) administration of arginine vasopressin (AVP) in unanaesthetized normotensive control and DOCA-salt hypertensive rats were studied. Intracerebroventricular administration of AVP (0.25-1000 ng) to control rats produced dose-dependent long-lasting increases in MAP (5-45 mmHg) and HR (35-110 beats/min). Peripheral treatment of rats with an antipressor AVP antagonist had no effect on i.c.v. AVP-induced… CONTINUE READING