Cardiovascular effects of human insular cortex stimulation

@article{Oppenheimer1992CardiovascularEO,
  title={Cardiovascular effects of human insular cortex stimulation},
  author={Stephen M. Oppenheimer and Adrian W. Gelb and John P. Girvin and Vladimir Hachinski},
  journal={Neurology},
  year={1992},
  volume={42},
  pages={1727 - 1727}
}
Recent investigations indicate a site of cardiac representation within the left insular cortex of the rat. Moreover, the results of lesion studies suggest left-sided insular dominance for sympathetic cardiovascular effects. It is unclear whether similar representation exists within the human insular cortex. Five epileptic patients underwent intraoperative insular stimulation prior to temporal lobectomy for seizure control. On stimulation of the left insular cortex, bradycardia and depressor… 

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References

SHOWING 1-10 OF 30 REFERENCES

Asymmetry of sympathetic consequences of experimental stroke.

Asymmetries of sympathetic regulation at the level of the inferior cervical ganglia have long been recognized, but this conclusion has remained tentative, since the differential effect of lateralized brain lesions on sympathetic activity has not been studied systematically.

Trigeminal neurotomy and blood pressure responses from stimulation of lateral cerebral cortex of Macaca mulatta.

The present study is an attempt to ascertain the entire extent of lateral neocortex from which blood pressure responses obtained from stimulation of various areas of the cerebral cortex are obtainable by using the stimulating techniques now available, and to begin to investigate whether or not a common mechanism links these various areas.

Frontal lobotomy and electrical stimulation of orbital surface of frontal lobes; effect on respiration and on blood pressure in man.

There appear to be four areas of the cerebral cortex which play a role in the regulation of autonomic activity, the motor areas 4 and 6, the anterior part of the cingulate gyrus (area 24), area 8 of the frontal lobe and the orbital surface ofThe frontal lobe.

Insula of the old world monkey. III: Efferent cortical output and comments on function

A collective consideration of afferents and efferents indicates that the insula has connections with principal sensory areas in the olfactory, gustatory, somesthetic, and auditory AI and AII modalities.

Insula of the old world monkey. Architectonics in the insulo‐orbito‐temporal component of the paralimbic brain

Observations of the insula of the rhesus monkey indicate that AChE histochemistry can be used for the architectonic analysis of cortex.

Unilateral cerebral inactivation produces differential left/right heart rate responses

The results are consistent with differential left/right cerebral hemispheric effects on autonomic function, and appear related to functional and anatomic asymmetries in both the central and peripheral nervous systems.

Cerebrogenic cardiac arrhythmias. Cerebral electrocardiographic influences and their role in sudden death.

Experimental evidence suggests that the insula has a cardiac chronotropic organization, and may be involved in the genesis of arrhythmias seen in epilepsy or after cerebral hemorrhage or stroke.