• Corpus ID: 23102262

Cardiovascular effects of carnosine.

  title={Cardiovascular effects of carnosine.},
  author={Pamela R. Roberts and Gary P. Zaloga},
  journal={Biochemistry. Biokhimiia},
  volume={65 7},
Carnosine (beta-alanyl-L-histidine) is an endogenous dipeptide found in various cells at millimolar concentration with its specific function(s) largely unknown. Our interests in therapeutic peptides led to the discovery that carnosine dramatically increases contractility when perfused into isolated rat hearts. Carnosine's effects are not mediated by histaminic or beta-adrenergic receptors or by increasing cyclic AMP, but carnosine does cause a rise in myoplasmic Ca(2+) concentration. In… 

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