• Corpus ID: 6381925

Cardiovascular effects of antihypertensive drugs as affected by dietary polyunsaturates.

@article{Hoffmann1984CardiovascularEO,
  title={Cardiovascular effects of antihypertensive drugs as affected by dietary polyunsaturates.},
  author={Pascale Hoffmann and Christian Taube and Torsten Bartels and S. Heinemann and Werner F{\"o}rster},
  journal={Biomedica biochimica acta},
  year={1984},
  volume={43 8-9},
  pages={
          S195-8
        }
}
Polyunsaturate-rich vegetable oils (sunflower oil, linseed oil, primrose oil) augment the hypotensive effect of dihydralazine, clonidine and captopril in rats under different experimental conditions. Evidence has accumulated that these effects are mediated via changes in prostanoid formation and sympathetic activity. 
2 Citations

Release of Fatty Acids by Perfused Vascular Tissue in Normotensive and Hypertensive Rats

Although both diets reduced vascular reactivity, primrose oil was more effective with lower doses of norepinephrine whereas fish oil blunted the effects of both low and high doses of diazepam.

Fatty Acid Composition of Regular Rat Chow and of the Evening Primrose Oil or Fish Body Oil Added to the Chow Fatty acid

Although both diets reduced vascular reactivity, primrose oil was more effective with lower doses of norepinephrine whereas fish oil blunted the effects of both low and high doses of diazepam.