Cardiovascular effects of 14-deoxy-11,12-didehydroandrographolide and Andrographis paniculata extracts.

  title={Cardiovascular effects of 14-deoxy-11,12-didehydroandrographolide and Andrographis paniculata extracts.},
  author={Nattaporn Yoopan and Piengpen Thisoda and Nuchanart Rangkadilok and Somjed Sahasitiwat and Nanthanit Pholphana and Somsak Ruchirawat and Jutamaad Satayavivad},
  journal={Planta medica},
  volume={73 6},
Andrographis paniculata has been widely used as a traditional medicine for the treatment of common cold, diarrhea and hypertension. The three major active diterpenoids are andrographolide (AP1), 14-deoxy-11,12-didehydroandrographolide (AP3) and neoandrographolide (AP4). It has been reported that AP3 has hypotensive and vasorelaxation effects. However, there is only limited information on the cardiovascular effects of the other diterpenoids and crude extracts containing different levels of AP3… 

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A Diterpenoid, 14-Deoxy-11, 12-Didehydroandrographolide, in Andrographis paniculata Reduces Steatohepatitis and Liver Injury in Mice Fed a High-Fat and High-Cholesterol Diet

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The present paper deals with development and standardization of HPTLC method used for quantification of 14‐Deoxy‐11,12‐ didehydroandrographolide in Andrographis paniculata commonly known as Kalmegh,

3, 19-diacetyl-14-deoxy-11,12-didehydroandrographolide (srs27) antagonises inflammatory response and oxidative stress in in vitro and in vivo asthma models

SRS27 was less toxic compared with AGP, which suggests that a simple chemical modification of DDAG produces a compound with CysLT and NO inhibitory activity similar to AGP but maintained the toxicity profile similar to DDAG, it is interesting to note.

Andrographis paniculata extracts and major constituent diterpenoids inhibit growth of intrahepatic cholangiocarcinoma cells by inducing cell cycle arrest and apoptosis.

Andrographis paniculata could be a promising herbal plant for the alternative treatment of intrahepatic cholangiocarcinoma because of its potent cytotoxic activity against the growth of liver and bile duct cancer cells.

Changes in the contents of four active diterpenoids at different growth stages in Andrographis paniculata (Burm.f.) Nees (Chuanxinlian)

In A. paniculata, AP6 was at the highest level in leaves at transfer stage in both greenhouse and field experiments, and AP1 was atThe highest level at leaves at vegetative stage and seed-forming stage in field and greenhouse experiments, respectively.