Corpus ID: 10300728

Cardiovascular effects of GABA, GABA-aminotransferase inhibitors and valproic acid following systemic administration in rats, cats and dogs: pharmacological approach to localize the site of action.

@article{Lscher1982CardiovascularEO,
  title={Cardiovascular effects of GABA, GABA-aminotransferase inhibitors and valproic acid following systemic administration in rats, cats and dogs: pharmacological approach to localize the site of action.},
  author={Wolfgang L{\"o}scher},
  journal={Archives internationales de pharmacodynamie et de therapie},
  year={1982},
  volume={257 1},
  pages={
          32-58
        }
}
  • W. Löscher
  • Published 1 May 1982
  • Chemistry, Medicine
  • Archives internationales de pharmacodynamie et de therapie
The cardiovascular effects of GABA, sodium valproate (VPA) and inhibitors of GABA-aminotransferase (GABA-T), namely aminooxyacetic acid, gabaculine, gamma-acetylenic GABA, gamma-vinyl GABA and ethanolamine-O-sulphate (EOS), were studied in anesthetized rats, cats and dogs. All compounds were administered intravenously in dose levels previously shown as anticonvulsant active. In rats and cats, GABA (100-1000 mg/kg) caused a sustained fall of blood pressure and heart rate. A similar reaction was… Expand
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