Corpus ID: 10300728

Cardiovascular effects of GABA, GABA-aminotransferase inhibitors and valproic acid following systemic administration in rats, cats and dogs: pharmacological approach to localize the site of action.

  title={Cardiovascular effects of GABA, GABA-aminotransferase inhibitors and valproic acid following systemic administration in rats, cats and dogs: pharmacological approach to localize the site of action.},
  author={Wolfgang L{\"o}scher},
  journal={Archives internationales de pharmacodynamie et de therapie},
  volume={257 1},
  • W. Löscher
  • Published 1 May 1982
  • Chemistry, Medicine
  • Archives internationales de pharmacodynamie et de therapie
The cardiovascular effects of GABA, sodium valproate (VPA) and inhibitors of GABA-aminotransferase (GABA-T), namely aminooxyacetic acid, gabaculine, gamma-acetylenic GABA, gamma-vinyl GABA and ethanolamine-O-sulphate (EOS), were studied in anesthetized rats, cats and dogs. All compounds were administered intravenously in dose levels previously shown as anticonvulsant active. In rats and cats, GABA (100-1000 mg/kg) caused a sustained fall of blood pressure and heart rate. A similar reaction was… Expand
Novel GABA analogues as hypotensive agents
The fact that these analogues mimicked the action of GABA on the cardiovascular system of the cat and that they were able to inhibit binding to GABAA receptors, indicates that they may be GABA agonists. Expand
Involvement of γ-Aminobutyric Acid (GABA) B Receptors in the Hypotensive Effect of Systemically Administered GABA in Spontaneously Hypertensive Rats
We investigated the effects of intraduodenally (i.d.) administered γ-aminobutyric acid (GABA) on blood pressure (BP) in anesthetized spontaneously hypertensive rats (SHR) and the mechanism underlyingExpand
Opioid and prostaglandin mechanisms involved in the effects of GABAergic drugs on body temperature.
The present results suggest that involvement of prostaglandins in the effects of GABA, muscimol and baclofen, while endogenous opiates seem to be implicated only in bacl ofen induced hyperthermia. Expand
Involvement of bicuculline-insensitive receptors in the hypothermic effect of GABA and its agonists.
It is concluded that GABA and GABA-agonists (DAVA and VPA) may induce hypothermia partly mediated by activation of bicuculline-insensitive GABA-receptors. Expand
Graded increases in brain GABA: Differential effects on feeding and other behaviours in rats
The notion that feeding decreases induced by low doses of GABA-T inhibitors may reflect a fairly specific effect on appetite mechanisms, but also indicate that with increasingly higher doses several other deficits are likely to contribute to the overall decrease in food intake is supported. Expand
Enhanced Depressor Effect of Muscimol in the DOCA/NaCl Hypertensive Rat: Evidence for Altered GABAergic Activity in Brain 1
  • S. Nagahama, R. Dawson, S. Oparil
  • Chemistry, Medicine
  • Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1985
The results suggest that the activity of the central GABAergic system is altered in the rat with established DOCA/NaCl hypertension and that the alteration incentral GABAergic function may be related to the increased sympathoadrenal activity and the maintenance of hypertension in this model. Expand
Comparison of the Effects of Valproate, Ethosuximide, Phenytoin, and Pentobarbital on Cerebral Energy Metabolism in the Rat
The sparing effect on ATP utilization may be related to a membrane‐stabilizing effect and may provide brain protection in case of excessive neuronal activation. Expand
The GABA/benzodiazepine receptor complex in the nervous system of a hypertensive strain of rat
The results indicate that in this model of hypertension, neither GABA nor glutamate function are involved, at least not in the cerebral cortex or cerebellum. Expand
Effects of gamma-vinyl GABA (vigabatrin) on blood pressure and body weight of hypertensive and normotensive rats
It is concluded that an increase in the GABA level in the brain leads to a delay in the development of hypertension in young SHR, and development of genetic hypertension seems to be susceptible to activation of the GABAergic system in a very early critical phase only. Expand
Role of the GABA chloride ion channel component on aggressive behavior in the male crab
Both the behavioral and autoradiographic results suggest that the defensive type of aggression behavior in crustacean may not only be mediated by a peripherally controlled GABA-gated chloride ion flux but also by a central GABAergic mechanism. Expand