Cardiovascular effects and lethality of venom from nematocysts of the box-jellyfish Chiropsalmus quadrigatus (Habu-kurage) in anaesthetized rats.

@article{Noguchi2005CardiovascularEA,
  title={Cardiovascular effects and lethality of venom from nematocysts of the box-jellyfish Chiropsalmus quadrigatus (Habu-kurage) in anaesthetized rats.},
  author={Katsuhiko Noguchi and Mayuko Sakanashi and Toshihiro Matsuzaki and Junko Nakasone and Tomoyuki Koyama and Naobumi Hamadate and Matao Sakanashi},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={2005},
  volume={45 4},
  pages={
          519-26
        }
}
Haemodynamic effects of saline-extracted venom from nematocysts isolated from Chiropsalmus quadrigatus (Habu-kurage) were studied in anaesthetized rats. Intravenous administration of venom (0.2-5 microg protein/kg) produced immediately dose-dependent hypertension and bradycardia. Femoral blood flow transiently increased but calculated femoral vascular conductance decreased. Changes caused by 1 microg/kg of venom were reproducible, and were not affected by prazosin, atropine or BQ123 (ET(A… CONTINUE READING
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