Cardiovascular diseases: protective effects of melatonin

@article{Tengattini2008CardiovascularDP,
  title={Cardiovascular diseases: protective effects of melatonin},
  author={Sandra Tengattini and Russel Joseph Reiter and Dun-Xian Tan and Mar{\'i}a Pilar Terr{\'o}n and Luigi Fabrizio Rodella and Rita Rezzani},
  journal={Journal of Pineal Research},
  year={2008},
  volume={44}
}
Abstract:  This brief review considers some of the cardiac diseases and conditions where free radicals and related reactants are believed to be causative. The report also describes the beneficial actions of melatonin against oxidative cardiovascular disorders. Based on the data available, melatonin seems to have cardioprotective properties via its direct free radical scavenger and its indirect antioxidant activity. Melatonin efficiently interacts with various reactive oxygen and reactive… 
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The role of melatonin in acute myocardial infarction.
TLDR
It is expected that melatonin administration could play a clinically relevant role in the pharmacotherapy of ischemic heart disease; an assumption supported by low toxicity and high safety of melatonin.
A Review of Biological and Pharmacological Actions of Melatonin: Oxidant and Prooxidant Properties
TLDR
Although melatonin could potentially be useful but safety, efficacy remains uncertain, the studies which document the influence of melatonin on the various oxidative stress associated diseases are reviewed.
A review of melatonin as a suitable antioxidant against myocardial ischemia–reperfusion injury and clinical heart diseases
TLDR
The information summarized in this review should serve as a comprehensive reference for the action of melatonin in cardioprotection and hopefully will contribute to the design of future experimental research.
Melatonin attenuates chemical-induced cardiotoxicity
TLDR
The therapeutic potential of melatonin in treatment of cardiotoxicities caused by various chemicals along with suggested molecular mechanisms of action for melatonin is reviewed.
Cardioprotective effects of melatonin: Focusing on its roles against diabetic cardiomyopathy.
Vascular endothelial cells and dysfunctions: role of melatonin.
TLDR
Melatonin administration has endothelium-protective potential in several pathological conditions, but it still needs to be established, whether melatonin is able to revert already established endothelial dysfunction in these conditions.
The Protective Effect of Melatonin on the Heart
TLDR
The potential of melatonin as a therapeutic agent for humans is strengthened by the finding that it ameliorates tissue damage in ischaemia/reperfusion in a number of organs.
Melatonin: Protection against age-related cardiac pathology
Peripheral and Central Effects of Melatonin on Blood Pressure Regulation
TLDR
The increased level of serum melatonin observed in some types of hypertension may be a counter-regulatory adaptive mechanism against the sympathetic overstimulation, and could become regularly involved in the struggle against this widespread cardiovascular pathology.
Melatonin affords protection against myocardial ischemia-induced cerebral mitochondrial dysfunction: an in vivo study.
Background: Ischemic Heart Disease (IHD) is a health problem of global concern. The studies on myocardial ischemia induced changes in brain particularly cerebrum portion are scanty. Lacunae exist in…
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References

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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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