• Corpus ID: 25597709

Cardiovascular diseases: oxidative damage and antioxidant protection.

  title={Cardiovascular diseases: oxidative damage and antioxidant protection.},
  author={P.-Y. Zhang and X Xu and X-C Li},
  journal={European review for medical and pharmacological sciences},
  volume={18 20},
  • P.-Y. ZhangX. XuX-C Li
  • Published 1 October 2014
  • Biology
  • European review for medical and pharmacological sciences
Atherosclerosis, the hardening of arteries under oxidative stress is related to oxidative changes of low density lipoproteins (LDL). The antioxidants prevent the formation of oxidized LDL during atherogenesis. Perhaps more than one mechanism is involved in the atherosclerosis disease where LDL is oxidized in all the cells of arterial wall during the development of this disease. The oxidation of LDL produces lipid peroxidation products such as isoprostans from arachidonic, eicosapentaenoic and… 

Detrimental Effects of Lipid Peroxidation in Type 2 Diabetes: Exploring the Neutralizing Influence of Antioxidants

The current review explores the pathological relevance of elevated lipid peroxidation products in T2D, especially highlighting their potential role as biomarkers and therapeutic targets in disease severity and the implication of some prominent antioxidant enzymes/factors involved in the blockade of lipidperoxidation.

Alterations of antioxidant status in asymptomatic hypercholesterolemic individuals after resveratrol intake

It is suggested that resveratrol acts synergistically with other antioxidants against oxidative stress and highlights the importance of hypercholesterolemic individuals consuming natural antioxidants instead of medications to reduce the risk of CVD, while the situation is still reversible.

Diseases Related to Types of Free Radicals

  • N. Maddu
  • Biology, Chemistry
  • 2019
The aim of the present study is that the free radicals may react with biomolecules of the cells and play an important role in the development of chronic disease conditions in the humans.

Obesity-Related Oxidative Stress: the Impact of Physical Activity and Diet Manipulation

The role of oxidative stress and inflammation as associated with obesity-related diseases, the potential concerns and benefits of exercise-mediated oxidative stress, and the advantageous role of dietary modification, including acute or chronic caloric restriction and vitamin D supplementation are discussed.

Oxidative Stress-Related Susceptibility to Aneurysm in Marfan’s Syndrome

The impact of oxidative stress on aneurysm formation in patients with Marfan’s syndrome as well as on possible beneficial effects of some agents with antioxidant properties are concentrated.

Systemic oxidoreductive balance in patients without clinical manifestation of atherosclerosis

Oxidative stress has clinical importance in the early stages of atherosclerosis and may be helpful in predicting its subclinical stage, and further studies are needed to determine the usefulness of tocopherol determination as a biomarker for Atherosclerosis risk evaluation.

Role of Oxidative Stress in Cardiac Dysfunction and Subcellular Defects Due to Ischemia-Reperfusion Injury

Analysis of results from isolated hearts perfused with or without some antioxidant treatments before subjecting to I/R injury has indicated that cardiac dysfunction is associated with the development of oxidative stress, intracellular Ca2+-overload and protease activation, and cardiac dysfunction as a consequence of I/ R injury to the heart.

C-Reactive Protein and High-Sensitive Cardiac Troponins Correlate with Oxidative Stress in Valvular Heart Disease Patients

Dysregulated oxidative stress contributes to the progression of VHD via positively correlating with CRP, hs-TnI, and hs -TnT level.



Review of human studies on oxidative damage and antioxidant protection related to cardiovascular diseases.

One single assay of lipid peroxidation is probably not sufficient to serve as a marker for cardiovascular risk and there is a need for measurements of several markers; the use of biomarkers provides a logical scientific basis for major intervention trials of antioxidants.

Oxidative damage and defense.

Overall, the present data suggest that protection against oxidative damage and related disease is best served by the variety of antioxidant substances found in fruit and vegetables.

Diabetes, oxidative stress, and antioxidants: A review

There is a need to continue to explore the relationship between free radicals, diabetes, and its complications, and to elucidate the mechanisms by which increased oxidative stress accelerates the development of diabetic complications, in an effort to expand treatment options.

Oxidative stress and the use of antioxidants in diabetes: Linking basic science to clinical practice

New strategies with classic as well as new antioxidants should be implemented in the treatment of diabetes, as it is becoming clear that rather than merely scavenging reactive radicals, a more comprehensive approach aimed at preventing the generation of these reactive species may prove more beneficial.

Role of antioxidants and oxidative stress in cardiovascular diseases

There are evidences suggesting increase intake of antioxidants to be protective in cardiovascular dis eases, however, irrational and non judicial use of antioxidants can also increase the risk of p otential toxicity.

The Changes of Superoxide Dismutase, Catalase and Glutathione Peroxidase Activities in Erythrocytes of Active and Passive Smokers

The results suggest that the increased oxidative stress occurs in smokers, owing to the free radicals present in smoke, which might cause a decrease in antioxidant enzyme activities and oxidant/antioxidant imbalance.

Extracellular superoxide dismutase.

Scavenger Receptors, Oxidized LDL, and Atherosclerosis

The persistence of receptors for OxLDL during evolution is probably accounted for by their role in recognition of ligands on the surfaces of oxidatively damaged or apoptotic cells, which has important implications in biology generally and specifically in atherogenesis, because apoptosis is a prominent feature of late lesions.

Paraoxonase1-192 Polymorphism Modulates the Nonfatal Myocardial Infarction Risk Associated With Decreased HDLs

Serum paraoxonase1 (PON1) appears to have a role in the protection of low density lipoproteins from oxidative stress, and the hypothesis that this polymorphism may modulate the myocardial infarction risk associated with low HDL cholesterol concentrations was tested.