Cardiovascular disease and nutrient antioxidants: role of low-density lipoprotein oxidation.

@article{Frei1995CardiovascularDA,
  title={Cardiovascular disease and nutrient antioxidants: role of low-density lipoprotein oxidation.},
  author={B. J. Frei},
  journal={Critical reviews in food science and nutrition},
  year={1995},
  volume={35 1-2},
  pages={
          83-98
        }
}
Increasing evidence indicates that oxidative modification of low-density lipoprotein (LDL) is causally related to atherosclerosis. Oxidatively modified LDL (oxLDL), in contrast to native LDL, is taken up avidly by macrophages, leading to formation of lipid-laden foam cells. Foam cells are pathognomonic of the atherosclerotic fatty streak. Modified LDL may also promote atherosclerosis by many other mechanisms, such as recruitment and retention of monocyte-macrophages, T-lymphocytes, and smooth… CONTINUE READING
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