Cardiovascular and renal actions of melanocyte-stimulating hormone peptides.

  title={Cardiovascular and renal actions of melanocyte-stimulating hormone peptides.},
  author={Michael H. Humphreys},
  journal={Current opinion in nephrology and hypertension},
  volume={16 1},
PURPOSE OF REVIEW Melanocyte stimulating hormones (MSHs, melanocortins) have important roles in feeding and energy metabolism and in inflammation. Recent observations have uncovered major functions for these peptides, particularly gamma-MSH, in cardiovascular regulation and sodium metabolism. RECENT FINDINGS Both alpha- and gamma-MSH acutely elevate blood pressure and heart rate through central stimulation of sympathetic nervous outflow. This action of alpha-MSH is mediated by the… CONTINUE READING
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