Cardiovascular and lethal effects of cocaine in anesthetized dogs and guinea-pigs.

Cardiovascular and lethal effects of i.v. cocaine infusion were studied in anesthetized mongrel dogs and Hartley guinea-pigs. Dogs were anesthetized with enflurane (2.25 vol%) or urethane (1500-1700 mg/kg i.v.) and guinea-pigs with urethane (1000 mg/kg i.p.). The rate of i.v. cocaine infusion was 0.91 mg/kg/min for dogs and 1.9 mg/kg/min for guinea-pigs. In… CONTINUE READING