Cardiovascular and adenylate cyclase stimulant properties of NKH477, a novel water-soluble forskolin derivative.

@article{Hosono1992CardiovascularAA,
  title={Cardiovascular and adenylate cyclase stimulant properties of NKH477, a novel water-soluble forskolin derivative.},
  author={Masayo Hosono and Tomonari Takahira and Ayumi Fujita and R Fujihara and Okihiko Ishizuka and T Tatee and Ko Nakamura},
  journal={Journal of cardiovascular pharmacology},
  year={1992},
  volume={19 4},
  pages={625-34}
}
The cardiovascular effects of NKH477 (6-(3-dimethylaminopropionyl)forskolin hydrochloride), a novel water-soluble forskolin derivative, were investigated in dogs. Intravenous (i.v.) injections of NKH477 (1-30 micrograms/kg) caused dose-related increases in left ventricular dP/dtmax (LVdP/dtmax), coronary and femoral artery blood flow (CBF, FBF), heart rate (HR), and myocardial oxygen consumption (MVO2) and a dose-related decrease in blood pressure (BP) in anesthetized dogs. The regression… CONTINUE READING