Cardiovascular actions of kynuramine and 5-hydroxykynuramine in pithed rats

@article{Charlton1983CardiovascularAO,
  title={Cardiovascular actions of kynuramine and 5-hydroxykynuramine in pithed rats},
  author={K. G. Charlton and Troy D. Johnson and A. T. Hamed and David E Clarke},
  journal={Journal of Neural Transmission},
  year={1983},
  volume={57},
  pages={199-211}
}
Kynuramines occur endogenously in brain and peripheral tissues as metabolites of indoleamino acids and indolamines but little is known regarding their possible physiological and/or pharmacological activity. The present study has investigated the effects of kynuramine and 5-hydroxykynuramine on the cardiovascular system of pithed rats and attempted to correlate effects seen on adrenergic and serotonergic receptors with ligand binding experiments donein vitro using rat brain membranes. Kynuramine… CONTINUE READING