Cardiovascular action of verapamil in the dog with particular reference to myocardial contractility and atrioventricular conduction.

@article{Angus1976CardiovascularAO,
  title={Cardiovascular action of verapamil in the dog with particular reference to myocardial contractility and atrioventricular conduction.},
  author={James A. S. Angus and David R. Richmond and P Dhumma-Upakorn and L. B. Cobbin and Alan H. Goodman},
  journal={Cardiovascular research},
  year={1976},
  volume={10 6},
  pages={623-32}
}
Verapamil (Isoptin) caused a dose-dependent peripheral vasodilation, increase in myocardial contractility, and tachycardia in the anaesthetized dog. Propranolol pretreatment blocked the cardiac stimulation following verapamil but the vasodilation was unaltered. Inflation of a thoracic aortic balloon prevented the fall in intravascular pressure and reduced the tachycardia and positive inotropic responses. These experiments suggest that clinical doses of verapamil cause peripheral vasodilation… CONTINUE READING

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