Cardiovascular abnormalities in Folr1 knockout mice and folate rescue.

  title={Cardiovascular abnormalities in Folr1 knockout mice and folate rescue.},
  author={Huiping Zhu and Bogdan J. Wlodarczyk and Melissa M. Scott and Wei Yu and Michelle Y Merriweather and Janee B Gelineau-van Waes and Robert J. Schwartz and Richard H. Finnell},
  journal={Birth defects research. Part A, Clinical and molecular teratology},
  volume={79 4},
BACKGROUND Periconceptional folic acid supplementation is widely believed to aid in the prevention of neural tube defects (NTDs), orofacial clefts, and congenital heart defects. Folate-binding proteins or receptors serve to bind folic acid and 5-methyltetrahydrofolate, representing one of the two major mechanisms of cellular folate uptake. METHODS We herein describe abnormal cardiovascular development in mouse fetuses lacking a functional folate-binding protein gene (Folr1). We also performed… CONTINUE READING


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