Cardiovascular System Effects of Marijuana
@article{Jones2002CardiovascularSE, title={Cardiovascular System Effects of Marijuana}, author={Reese T. Jones}, journal={The Journal of Clinical Pharmacology}, year={2002}, volume={42} }
Marijuana and Δ9‐tetrahydrocannabinol (THC) increase heart rate, slightly increase supine blood pressure, and on occasion produce marked orthostatic hypotension. Cardiovascular effects in animals are different, with bradycardia and hypotension the most typical response. Cardiac output increases, and peripheral vascular resistance and maximum exercise performance decrease. Tolerance to most of the initial cardiovascular effects appears rapidly. With repeated exposure, supine blood pressure…
273 Citations
Acute effects of oral delta-9-tetrahydrocannabinol (THC) on autonomic cardiac activity and their relation to subjective and anxiogenic effects.
- Medicine, PsychologyPsychophysiology
- 2021
The present study is one of the first to characterize the effects of single doses of oral THC on autonomic nervous system function in healthy adult women and extend the knowledge of the autonomic effects of THC in relation to subjective drug experience.
The Impact of Marijuana on the Cardiovascular System: A Review of the Most Common Cardiovascular Events Associated with Marijuana Use
- Medicine, BiologyJournal of clinical medicine
- 2020
The aim of this review is to provide a basic understanding of the physiological effects of marijuana on the cardiovascular system and to review the current literature regarding cardiovascular diseases linked to marijuana use in adults.
Endocannabinoids, Blood Pressure and the Human Heart
- Medicine, BiologyJournal of neuroendocrinology
- 2008
Rimonabant, the CB1 receptor blocker in clinical use in many countries, induced a marked and sustained increase in cardiac contractility and blood pressure in hypertensive rats but, on the contrary, contributed to decreaseBlood pressure in weight‐loss clinical trials especially in obese patients with hypertension.
Role of cannabis in cardiovascular disorders.
- Biology, MedicineJournal of thoracic disease
- 2017
More efforts are needed to increase awareness among the public, especially youth, about the cardiovascular risks associated with cannabis use and to disseminate the accumulated knowledge regarding its ill effects.
Adverse cardiovascular, cerebrovascular, and peripheral vascular effects of marijuana inhalation: what cardiologists need to know.
- MedicineThe American journal of cardiology
- 2014
Cardiovascular Complications of Marijuana and Related Substances: A Review
- Biology, MedicineCardiology and Therapy
- 2017
There are reasons to believe that older individuals and those with risk factors for or established cardiovascular disease are at even higher danger of such events following exposure to cannabis.
The complexities of the cardiovascular actions of cannabinoids
- BiologyBritish journal of pharmacology
- 2004
The cardiovascular actions of cannbinoids are complex and in conscious animals, the picture is one of bradycardia followed by pressor responses, but clearly the responses to cannabinoids are dependent on the experimental conditions and synthetic cannabinoids and endocannabinoids exhibit different pharmacologies.
Cannabinoids as therapeutic agents in cardiovascular disease: a tale of passions and illusions
- BiologyBritish journal of pharmacology
- 2007
The present review examines the effects of cannabinoids and of the pharmacological manipulation of the endocannabinoid system, in cardiovascular pathophysiology.
At the heart of the matter: the endocannabinoid system in cardiovascular function and dysfunction.
- Biology, MedicineTrends in pharmacological sciences
- 2012
References
SHOWING 1-10 OF 77 REFERENCES
Cardiovascular effects of prolonged delta‐9‐tetrahydrocannabinol ingestion
- MedicineClinical pharmacology and therapeutics
- 1975
Impaired circulatory responses to standing, exercise, Valsalva maneuver, and cold pressor testing suggest a state of sympathetic insufficiency, and nearly complete tolerance developed to the tachycardia and psychological effects produced by smoked marijuana while ingesting THC.
Cardiovascular and Metabolic Considerations in Prolonged Cannabinoid Administration in Man
- Biology, MedicineJournal of clinical pharmacology
- 1981
Cardiovascular effects of acute Δ9‐tetrahydrocannabinol (THC) administration included increased sympathetic and reduced parasympathetic tone, although sympathetic reflex responses were impaired.
The cardiovascular and autonomic effects of repeated administration of delta-9-tetrahydrocannabinol to rhesus monkeys.
- Medicine, BiologyThe Journal of pharmacology and experimental therapeutics
- 1981
The response of basal heart rate to antagonists and the augmented reflex bradycardia suggest that THC alters autonomic control of the cardiovascular system resulting in parasympathetic dominance.
Intravenous Δ9‐Tetrahydrocannabinol: Effects on Ventilatory Control and Cardiovascular Dynamics
- Medicine
- 1975
Intense mental effects and anxiety prohibited higher THC doses, and the cardiovascular changes suggest betaadrenergic stimulation.
Some cardiovascular effects of marihuana smoking in normal volunteers
- MedicineClinical pharmacology and therapeutics
- 1971
Systolic and diastolic blood pressures were significantly elevated after total doses of marihuana containing more than 10 mg.
Cardiovascular effects of intravenous delta‐9‐tetrahydrocannabinol: Autonomic nervous mechanisms
- Medicine, BiologyClinical pharmacology and therapeutics
- 1979
The data suggest that THC acts to induce sympathetic stimulation and parasympathetic inhibition of cardiovascular control pathways in normal subjects and in patients who developed hypertension after either intravenous or smoked marijuana.
Intravenous delta9-Tetrahydrocannabinol: Effects of ventilatory control and cardiovascular dynamics.
- MedicineAnesthesiology
- 1975
Dose-related tachycardia was the most marked cardiovascular effect, and the cardiovascular changes suggest beta-adrenergic stimulation.
Cardiovascular actions of cannabinoids and their generation during shock
- BiologyJournal of Molecular Medicine
- 1998
Recent studies indicate that a peripheral endogenous cannabinoid system in circulating macrophages and platelets is activated in hemorrhagic and septic shock and may contribute to the hypotension associated with these conditions via activation of vascular cannabinoid receptors.
Cardiovascular Effects of Cannabinol During Oral Surgery
- MedicineAnesthesia and analgesia
- 1976
It was concluded that THC had no particular advantage over diazepam or placebo as a premedicant, but altered the patients' adaptivity to stress and interacted undesirably with other anesthetic medications.