Cardiovascular Safety of Anagrelide in Healthy Subjects: Effects of Caffeine and Food Intake on Pharmacokinetics and Adverse Reactions

@article{MartnezSells2012CardiovascularSO,
  title={Cardiovascular Safety of Anagrelide in Healthy Subjects: Effects of Caffeine and Food Intake on Pharmacokinetics and Adverse Reactions},
  author={Manuel Mart{\'i}nez‐Sell{\'e}s and Tomas Datino and Lourdes M Figueiras-Graillet and J. Gustavo Vega Gama and Christopher Jones and Richard Arthur Franklin and Francisco Fern{\'a}ndez‐Avil{\'e}s},
  journal={Clinical Drug Investigation},
  year={2012},
  volume={33},
  pages={45 - 54}
}
BackgroundEssential thrombocythaemia (ET) is a rare clonal myeloproliferative disorder characterized by a sustained elevation in platelet count and megakaryocyte hyperplasia. Anagrelide is used in the treatment of ET, where it has been shown to reduce platelet count. Anagrelide is metabolized by cytochrome P450 (CYP) 1A2, and previous studies of the effect of food on the bioavailability and pharmacokinetics of anagrelide were conducted prior to the identification of the active metabolite, 3… 
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