Cardiovascular Response to 8-Hydroxy-2-(di-n-Propylamino) Tetralin (8-OH-DPAT) in the Rat: Site of Action and Pharmacological Analysis

@article{Fozard1987CardiovascularRT,
  title={Cardiovascular Response to 8-Hydroxy-2-(di-n-Propylamino) Tetralin (8-OH-DPAT) in the Rat: Site of Action and Pharmacological Analysis},
  author={J. Fozard and A. Mir and D. Middlemiss},
  journal={Journal of Cardiovascular Pharmacology},
  year={1987},
  volume={9},
  pages={328-347}
}
Summary: The cardiovascular response to 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), a selective putative 5-HT1A receptor agonist, has been investigated in the rat. Comparisons were made with clonidine, a centrally acting hypotensive agent with negligible affinity for 5-HT receptors. In conscious, spontaneously hypertensive (SH) rats, 8-OH-DPAT caused dose-related and sustained falls in blood pressure and heart rate that were unaffected by depletion of brain 5-HT by p… Expand
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