Cardiovascular Complications of Opioid Use: JACC State-of-the-Art Review.

@article{Krantz2021CardiovascularCO,
  title={Cardiovascular Complications of Opioid Use: JACC State-of-the-Art Review.},
  author={Mori J Krantz and Robert B. Palmer and Mark C P Haigney},
  journal={Journal of the American College of Cardiology},
  year={2021},
  volume={77 2},
  pages={
          205-223
        }
}
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The case of a patient who unexpectedly developed an ‘apical ballooning’ with severe reduction in the LV systolic function and heart failure after the withdrawal of methadone supports the concept that increased sympathetic activity secondary to opioids withdrawal can trigger a stress-induced severe LV dysfunction.
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