Cardiovascular Autonomic Imbalance and Baroreflex Dysfunction in the Apolipoprotein E-deficient Mouse

@article{Vasquez2012CardiovascularAI,
  title={Cardiovascular Autonomic Imbalance and Baroreflex Dysfunction in the Apolipoprotein E-deficient Mouse},
  author={E. C. Vasquez and V. Peotta and S. S. Meyrelles},
  journal={Cellular Physiology and Biochemistry},
  year={2012},
  volume={29},
  pages={635 - 646}
}
Genetically engineered mouse models and advances in molecular biotechnology have given extensive aid to experimental studies of cardiovascular mechanisms and dysfunction in pathological states such as atherosclerosis. Among the available animal models that have been developed to study atherosclerosis, the apolipoprotein E-deficient (apoE-/-) mouse is the most ideal genetically modified animal presently available. The apoE-/-mouse develops spontaneous severe hypercholesterolemia in a short-time… Expand
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