Cardiovascular (β‐Adrenergic Blocking Effects of Bornaprolol in Humans: Relation to Dose and Plasma Concentration

@article{Cheymol1987CardiovascularB,
  title={Cardiovascular ($\beta$‐Adrenergic Blocking Effects of Bornaprolol in Humans: Relation to Dose and Plasma Concentration},
  author={Georges Cheymol and Patrice Jaillon and Bertrand Lecoq and V Lecoq and Andr{\'e} Cheymol and Michel Krumenacker},
  journal={Journal of Cardiovascular Pharmacology},
  year={1987},
  volume={9},
  pages={694–698}
}
The cardiovascular (β-blocking effects of bornaprolol were studied in healthy male volunteers after four single oral doses. The inhibition of isoproterenol-induced tachycardia was monitored for 72 h in six subjects, and the inhibition of exercise-induced tachycardia and rise of systolic blood pressure were monitored for 167 h in six other subjects. Plasma drug concentrations were determined by gas chromatography. Bornaprolol significantly reduced the resting heart rate, isoproterenol- and… 
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