Cardiotrophin-1 requires LIFRbeta to promote survival of mouse motoneurons purified by a novel technique.

Abstract

The cytokines ciliary neurotrophic factor (CNTF) and leukemia inhibitory factor (LIF) signal through a receptor complex formed between two transmembrane proteins, gp130 and LIFRbeta. In addition, CNTF also uses a ligand-binding component which is anchored to the cell membrane. In the case of cardiotrophin-1 (CT-1), LIFRbeta is also required in… (More)

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Cite this paper

@article{Arce1999Cardiotrophin1RL, title={Cardiotrophin-1 requires LIFRbeta to promote survival of mouse motoneurons purified by a novel technique.}, author={Vilma Arce and Alexandra Garces and B{\'e}atrice de Bovis and Pierre Filippi and Christopher E. Henderson and Brigitte Pettmann and Odile Delapeyri{\`e}re}, journal={Journal of neuroscience research}, year={1999}, volume={55 1}, pages={119-26} }