Cardiotrophin-1 is expressed in adipose tissue and upregulated in the metabolic syndrome.

@article{Natal2008Cardiotrophin1IE,
  title={Cardiotrophin-1 is expressed in adipose tissue and upregulated in the metabolic syndrome.},
  author={Cristina Natal and Mar{\'i}a Antonia Fortu{\~n}o and Patricia Restituto and Antonio Ray Baz{\'a}n and Immaculada Colina and J M Olivares D{\'i}ez and Nerea Varo},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2008},
  volume={294 1},
  pages={E52-60}
}
Adipose tissue is a target for cardiotrophin-1 (CT-1), a cytokine member of the IL-6 family of cytokines that is involved in cardiac growth and dysfunction. However, it is unknown whether adipocytes are a source of CT-1 and whether CT-1 is overexpressed in diseases characterized by increased fat depots [i.e., the metabolic syndrome (MS)]. Thus this work aimed 1) to test whether adipose tissue expresses CT-1 and whether CT-1 expression can be modulated and 2) to compare serum CT-1 levels in… CONTINUE READING
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