Cardiotrophin-1 is an essential factor in the natural defense of the liver against apoptosis.

  title={Cardiotrophin-1 is an essential factor in the natural defense of the liver against apoptosis.},
  author={Juan Mart{\'i}n Marqu{\'e}s and Idoia Belza and Bettina Holtmann and Diane Pennica and Jes{\'u}s Prieto and Matilde Bustos},
  volume={45 3},
UNLABELLED We previously reported that exogenous cardiotrophin-1 (CT-1), a member of the IL-6 family of cytokines, exerts hepatoprotective effects. Because CT-1 is expressed in the normal liver, we hypothesized that this cytokine may constitute an endogenous defense of the liver against proapoptotic stimuli. Here, we found that CT-1-/- mice died faster than wild-type animals after challenge with a lethal dose of the Fas agonist Jo-2. At sublethal doses of Jo-2, all wild-type mice survived… CONTINUE READING


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